GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs1930961 | 1 | rs997873 | chr22:25878282 | CRYBB2 | chr22:25615612-25627836:+ | 0.91 | 9.5 | 2.28E-19 | Bipolar disorder with mood-incongruent psychosis |
| BLCA | cis | rs2832077 | 1 | rs9983229 | chr21:30137674 | N6AMT1 | chr21:30244513-30257693:- | 0.29 | 4.75 | 2.84E-6 | Cognitive test performance |
| BLCA | cis | rs10935120 | 1 | rs9985356 | chr3:134232920 | ANAPC13 | chr3:134196547-134204865:- | -0.47 | -7.68 | 1.3E-13 | Height |
| BLCA | cis | rs853679 | 1 | rs9986596 | chr6:28219661 | ZNF389 | chr6:28129551-28137375:+ | -0.33 | -4.07 | 5.63E-5 | Depression |
| BLCA | cis | rs9783347 | 1 | rs9988866 | chr11:18392983 | GTF2H1 | chr11:18343816-18388590:+ | 0.3 | 5.59 | 4.32E-8 | Pancreatic cancer |
| BLCA | cis | rs10935120 | 1 | rs9989967 | chr3:134238964 | ANAPC13 | chr3:134196547-134204865:- | 0.47 | 7.49 | 4.72E-13 | Height |
| BLCA | cis | rs10935120 | 1 | rs9990351 | chr3:134239191 | ANAPC13 | chr3:134196547-134204865:- | -0.46 | -7.23 | 2.58E-12 | Height |
| BLCA | cis | rs2273 | 1 | rs9995007 | chr4:76897791 | NAAA | chr4:76831809-76862166:- | -0.37 | -6.16 | 1.88E-9 | Longevity |
| BLCA | trans | rs62295889 | 1 | rs10005460 | chr4:12580386 | KRTAP13-1 | chr21:31768392-31769136:+ | 0.15 | 6.43 | 3.77E-10 | Obesity-related traits |
| BLCA | trans | rs62295889 | 1 | rs10023638 | chr4:12576387 | KRTAP13-1 | chr21:31768392-31769136:+ | 0.15 | 6.21 | 1.4E-9 | Obesity-related traits |
| BLCA | trans | rs10037055 | 1 | rs10037055 | chr5:176691279 | LOC388955 | chr2:63849182-63850159:- | -0.54 | -11.98 | 2.71E-28 | Migraine without aura |
| BLCA | trans | rs1003719 | 1 | rs1003719 | chr21:38491095 | LZTFL1 | chr3:45865446-45957534:- | 0.31 | 6.1 | 2.54E-9 | Eye color traits |
| BLCA | trans | rs1056667 | 1 | rs10214634 | chr6:26564582 | ZNF322B | chr9:99957633-99961910:- | 0.46 | 8.07 | 9.07E-15 | Educational attainment |
| BLCA | trans | rs1056667 | 1 | rs10484442 | chr6:26555879 | ZNF322B | chr9:99957633-99961910:- | 0.46 | 8.01 | 1.43E-14 | Educational attainment |
| BLCA | trans | rs17065323 | 1 | rs10514847 | chr13:44626749 | MED4 | chr13:48627462-48669251:- | -0.88 | -6.11 | 2.52E-9 | Uric acid levels |